AJ2-30

• CAT Number: I040779
• CAS Number: 2700322-79-6
• Molecular Formula: C23H22N4
• Molecular Weight: 354.45
• Purity: ≥95%
• Synonyms: N-[(9-ethylcarbazol-3-yl)methyl]-1-methylbenzimidazol-2-amine
• InChI: InChI=1S/C23H22N4/c1-3-27-20-10-6-4-8-17(20)18-14-16(12-13-21(18)27)15-24-23-25-19-9-5-7-11-22(19)26(23)2/h4-14H,3,15H2,1-2H3,(H,24,25)
• InChIKey: QKZNLVHPKAXDOL-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C=C(C=C2)CNC3=NC4=CC=CC=C4N3C)C5=CC=CC=C51

AJ2-30 (Cat No.: I040779) is a potent small-molecule inhibitor of NLRP3 inflammasome activation, used in inflammation and immunology research. It selectively blocks NLRP3 without affecting other inflammasome pathways, such as AIM2 or NLRC4. AJ2-30 suppresses IL-1β release and caspase-1 activation, providing a valuable tool for exploring NLRP3-related diseases, including autoimmune disorders, neuroinflammation, and metabolic syndromes. Its specificity and efficacy make it ideal for dissecting inflammasome signaling and identifying therapeutic strategies targeting chronic inflammatory responses. For research use only.

Reference

[1]. Daniel Lazar, et al. Small molecule inhibitors of scl15a4 with anti-inflammatory activity. Patent. WO2021174023.