For research use only. Not for therapeutic Use.
AJ2-71 (Cat No.: I040780) is a selective and potent inhibitor of the NLRP3 inflammasome, structurally related to AJ2-30 but optimized for improved bioactivity. It effectively blocks NLRP3-mediated caspase-1 activation and IL-1β secretion without disrupting other inflammasome pathways such as AIM2 or NLRC4. AJ2-71 is valuable for studying chronic inflammatory diseases, including autoimmune and neurodegenerative conditions. Its specificity supports precise dissection of NLRP3 signaling mechanisms and evaluation of anti-inflammatory therapeutic strategies. For research use only in laboratory and preclinical settings.
| CAS Number | 2700323-17-5 |
| Synonyms | N-(1H-benzo[g]indol-3-ylmethyl)-1H-benzimidazol-2-amine |
| Molecular Formula | C20H16N4 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H16N4/c1-2-6-15-13(5-1)9-10-16-14(11-21-19(15)16)12-22-20-23-17-7-3-4-8-18(17)24-20/h1-11,21H,12H2,(H2,22,23,24) |
| InChIKey | VXDJUMYQUPVGOP-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC3=C2NC=C3CNC4=NC5=CC=CC=C5N4 |
| Reference | [1]. Daniel Lazar, et al. Small molecule inhibitors of scl15a4 with anti-inflammatory activity. Patent. WO2021174023. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
