AJH836

• CAT Number: I021651
• Molecular Formula: C22H38O5
• Molecular Weight: 382.541
• Purity: 98%
• Synonyms: AJH836; AJH 836; AJH-836
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (E)-(2-(hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxotetrahydrofuran-2-yl)methyl pivalate
• InChI: InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9+
• InChIKey: XKEOGEXDEKIDNA-GIJQJNRQSA-N
• SMILES: CC(C)(C)C(OCC1(CO)C/C(C(O1)=O)=CCC(CC(C)C)CC(C)C)=O

AJH836 is a PKC Activator.

Reference

1: Cooke M, Casado-Medrano V, Ann J, Lee J, Blumberg PM, Abba MC, Kazanietz MG. Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes. Sci Rep. 2019 Apr 15;9(1):6041. doi: 10.1038/s41598-019-42581-4. PMID: 30988374; PMCID: PMC6465381.
2: Casado-Medrano V, Barrio-Real L, Wang A, Cooke M, Lopez-Haber C, Kazanietz MG. Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells. Oncogene. 2019 Jul;38(27):5396-5412. doi: 10.1038/s41388-019-0796-4. Epub 2019 Mar 28. PMID: 30923343; PMCID: PMC6609469.
3: Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG. Characterization of AJH-836, a diacylglycerol- lactone with selectivity for novel PKC isozymes. J Biol Chem. 2018 Jun 1;293(22):8330-8341. doi: 10.1074/jbc.RA117.000235. Epub 2018 Apr 10. PMID: 29636415; PMCID: PMC5986226.