For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Ajmaline is an alkaloid that is class Ia antiarrhythmic agent.</p>
| Catalog Number | I000043 |
| CAS Number | 4360-12-7 |
| Molecular Formula | C20H26N2O2 |
| Purity | ≥95% |
| Target | Sodium Channel |
| Solubility | 4.09 g/L in H2O |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10-,11-,14-,15-,16-,17-,18+,19-,20+/m0/s1 |
| InChIKey | CJDRUOGAGYHKKD-KBPCXUENSA-N |
| SMILES | CN1[C@]2([C@@]3(C[C@H]4[C@@H]([C@H](O)N3[C@@H]5[C@H]4[C@@H](O)[C@@]2(C6=C1C=CC=C6)C5)CC)[H])[H] |
| Reference | </br>1:Should all individuals with a non-diagnostic electrocardiogram undergo ajmaline challenge to unmask the concealed arrhythmic overlap syndromes? Vedat Kavurt A, Ozeke O, Cay S, Topaloglu S, Aras D.Europace. 2017 Apr 12. doi: 10.1093/europace/eux084. [Epub ahead of print] No abstract available. PMID: 28419221 </br>2:Proarrhythmogenic effects of lamotrigine during ajmaline testing for Brugada syndrome. Leong KM, Seligman H, Varnava AM.HeartRhythm Case Rep. 2017 Jan 22;3(3):167-171. doi: 10.1016/j.hrcr.2016.11.006. eCollection 2017 Mar. No abstract available. PMID: 28344931 Free PMC Article</br>3:Systematic ajmaline challenge in patients with long QT 3 syndrome caused by the most common mutation: a multicentre study. Hohmann S, Rudic B, Konrad T, Duncker D, König T, Tülümen E, Rostock T, Borggrefe M, Veltmann C.Europace. 2016 Dec 2. pii: euw214. [Epub ahead of print] PMID: 27915266 </br>4:Ajmaline Challenge To Unmask Infrahisian Disease In Patients With Recurrent And Unexplained Syncope, Preserved Ejection Fraction, With Or Without Conduction Abnormalities On Surface ECG. Pentimalli F, Bacino L, Ghione M, Giambattista S, Gazzarata M, Bellotti P.J Atr Fibrillation. 2016 Aug 31;9(2):1421. doi: 10.4022/jafib.1421. eCollection 2016 Aug-Sep. PMID: 27909532 Free PMC Article</br>5:Rauvolfia serpentina N-methyltransferases involved in ajmaline and Nβ -methylajmaline biosynthesis belong to a gene family derived from γ-tocopherol C-methyltransferase. Cázares-Flores P, Levac D, De Luca V.Plant J. 2016 Aug;87(4):335-42. doi: 10.1111/tpj.13186. Epub 2016 Aug 3. PMID: 27122470 </br>6:Ventricular arrhythmia during ajmaline challenge for the Brugada syndrome. Dobbels B, De Cleen D, Ector J.Europace. 2016 Oct;18(10):1501-1506. Epub 2016 Mar 3. Review. PMID: 26941343 </br>7:Subcutaneous implantable cardioverter-defibrillator and drug-induced Brugada syndrome: the importance of repeat morphology analysis during ajmaline challenge. Conte G, Regoli F, Moccetti T, Auricchio A.Eur Heart J. 2016 May 14;37(19):1498. doi: 10.1093/eurheartj/ehv572. Epub 2015 Nov 3. No abstract available. PMID: 26530106 </br>8:Usefulness of patient/’s history and non-invasive electrocardiographic parameters in prediction of ajmaline test results in patients with suspected Brugada syndrome. Uziębło-Życzkowska B, Gielerak G, Michałkiewicz D.Arch Med Sci. 2014 Oct 27;10(5):899-912. doi: 10.5114/aoms.2013.36928. Epub 2013 Aug 12. PMID: 25395941 Free PMC Article</br>9:Ventricular fibrillation induction and diffuse abnormal ST-segment response to ajmaline in a patient with apparent pre-existing dynamic right bundle branch block. Nguyen BL, Tufano F, De Angelis S, Tersigni F, Alessandri N, Brugada P.Eur Rev Med Pharmacol Sci. 2014 Oct;18(20):3115-9. PMID: 25392113 Free Article</br>10:The challenges of performing ajmaline challenge in children with suspected Brugada syndrome. Conte G, Brugada P.Open Heart. 2014 Feb 20;1(1):e000031. doi: 10.1136/openhrt-2013-000031. eCollection 2014. No abstract available. PMID: 25332790 Free PMC Article |
