For research use only. Not for therapeutic Use.
AK-IN-1 (compound 4072-2732) is an adenosine kinase (AK) inhibitor that is competitive for adenosine (Ado) but not for ATP. AK-IN-1 inhibits 86%, 87% and 89% of AK activity at concentrations of 2, 4 and 10 µM, respectively. AK-IN-1 has good potential for research in many disease areas, including ischaemia, inflammation and seizures[1].
| Catalog Number | I042628 |
| CAS Number | 378775-98-5 |
| Synonyms | 2-[[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino]ethanol |
| Molecular Formula | C22H21N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H21N3O4/c1-27-16-7-3-14(4-8-16)18-19-21(23-11-12-26)24-13-25-22(19)29-20(18)15-5-9-17(28-2)10-6-15/h3-10,13,26H,11-12H2,1-2H3,(H,23,24,25) |
| InChIKey | ARBUGBBNEFAECO-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C2=C(OC3=NC=NC(=C23)NCCO)C4=CC=C(C=C4)OC |
| Reference | [1]. Park J, et al. Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase. Protein J. 2007 Apr;26(3):203-12. |
