For research use only. Not for therapeutic Use.
AKB-6899（Cat No.:I021672） is a compound that promotes the stabilization of HIF-2α, a transcription factor involved in cellular response to low oxygen levels. This stabilization leads to the production of sVEGFR-1 (soluble vascular endothelial growth factor receptor-1) by tumor-associated macrophages. The increase in sVEGFR-1 levels helps suppress tumor growth in a murine melanoma model. AKB-6899’s ability to modulate the HIF-2α pathway and manipulate the tumor microenvironment holds potential for the development of novel therapeutic approaches targeting angiogenesis and tumor progression.
| Catalog Number | I021672 |
| CAS Number | 1007377-55-0 |
| Synonyms | AKB-6899; AKB 6899; AKB6899 |
| Molecular Formula | C14H11FN2O4 |
| Purity | 98% |
| Target | HIF/HIF Prolyl-Hydroxylase |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| IUPAC Name | N-((5-(3-Fluorophenyl)-3-hydroxy-2-pyridinyl)carbonyl)glycine |
| InChI | InChI=1S/C14H11FN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20) |
| InChIKey | PXWOWORYDKAEJO-UHFFFAOYSA-N |
| SMILES | O=C(O)CNC(C1=NC=C(C2=CC=CC(F)=C2)C=C1O)=O |
| Reference | 1: Roda JM, Wang Y, Sumner LA, Phillips GS, Marsh CB, Eubank TD. Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model. J Immunol. 2012 Sep 15;189(6):3168-77. doi: 10.4049/jimmunol.1103817. Epub 2012 Aug 6. PubMed PMID: 22869907; PubMed Central PMCID: PMC3436995. |
