AKBA

• CAT Number: I004532
• CAS Number: 67416-61-9
• Molecular Formula: C32H48O5
• Molecular Weight: 512.71
• Purity: ≥95%
• Synonyms: 3-O-acetyl-11-keto-β-Boswellic acid;AKBA
• Target: NF-κB
• Solubility: DMSO: ≥ 5 mg/mL
• Storage: -20°C
• IUPAC Name: (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetyloxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4a,5,6,7,8,9,10,11,12,12a,14a-tetradecahydropicene-4-carboxylic acid
• InChI: InChI=1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1
• InChIKey: HMMGKOVEOFBCAU-HUXDCABZSA-N
• SMILES: C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC(=O)[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@H]([C@]5(C)C(=O)O)OC(=O)C)C)C)[C@@H]2[C@H]1C)C)C

Acetyl-11-Keto-β-Boswellic Acid (AKBA)(CAT: I004532) is a bioactive triterpenoid compound derived from the resin of Boswellia serrata. It is well-known for its potent anti-inflammatory, anticancer, and neuroprotective properties. AKBA functions as a novel Nrf2 activator, promoting the activation of the Nrf2 (nuclear factor erythroid 2–related factor 2) pathway, which enhances the expression of antioxidant and cytoprotective genes. This activation helps combat oxidative stress and inflammation, making AKBA a promising candidate in inflammation, cancer, and neurodegenerative disease research. Its multi-targeted actions support therapeutic exploration for chronic diseases driven by oxidative damage and inflammation.