For research use only. Not for therapeutic Use.
AKOS-22 (Cat No.: I021681) is a synthetic small molecule known for its potential inhibitory activity against specific enzyme targets, particularly in cancer and inflammatory disease research. While detailed pharmacological data is limited, AKOS-22 is often used as a reference compound in biochemical assays and structure-activity relationship (SAR) studies. It may exhibit properties such as enzyme inhibition or receptor modulation, depending on the biological system tested. AKOS-22 serves as a useful research tool in drug discovery and mechanistic studies across various therapeutic areas.
| CAS Number | 878983-38-1 |
| Synonyms | AKOS-22; AKOS 22; AKOS22; AKOS-022075291; AKOS 022075291; AKOS022075291 |
| Molecular Formula | C22H21ClF3N3O3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 1-(4-Chloro-phenyl)-3-[4-(4-trifluoromethoxy-phenylamino)-piperidin-1-yl]-pyrrolidine-2,5-dione |
| InChI | InChI=1S/C22H21ClF3N3O3/c23-14-1-5-17(6-2-14)29-20(30)13-19(21(29)31)28-11-9-16(10-12-28)27-15-3-7-18(8-4-15)32-22(24,25)26/h1-8,16,19,27H,9-13H2 |
| InChIKey | ZZVCWIMICOFQNJ-UHFFFAOYSA-N |
| SMILES | O=C(C(N1CCC(NC2=CC=C(OC(F)(F)F)C=C2)CC1)C3)N(C4=CC=C(Cl)C=C4)C3=O |
| Reference | Danya Ben-Hail 1 , Racheli Begas-Shvartz 1 , Moran Shalev 1 , Anna Shteinfer-Kuzmine 1 , Arie Gruzman 2 , Simona Reina 3 ,4 , Vito De Pinto 3 and Varda Shoshan-Barmatz 1, * Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondria dysfunction. JBC Papers in Press. Published on October 13, 2016 as Manuscript M116.744284. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
