AKR1C3-IN-1

• CAT Number: I013175
• CAS Number: 327092-81-9
• Molecular Formula: C₁₆H₁₅NO₄S
• Molecular Weight: 317.36
• Purity: ≥95%
• Target: Others
• Solubility: DMSO: ≥ 100 mg/mL
• IUPAC Name: 3-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzoic acid
• InChI: InChI=1S/C16H15NO4S/c18-16(19)13-6-3-7-15(10-13)22(20,21)17-9-8-12-4-1-2-5-14(12)11-17/h1-7,10H,8-9,11H2,(H,18,19)
• InChIKey: ZGVIUMKHTXKKOX-UHFFFAOYSA-N
• SMILES: C1CN(CC2=CC=CC=C21)S(=O)(=O)C3=CC=CC(=C3)C(=O)O

AKR1C3-IN-1(CAT: I013175) is a remarkable compound in the field of pharmaceutical and enzyme inhibition research. Functioning as a potent and highly selective inhibitor of AKR1C3 (aldo-keto reductase 1C3), it holds significant potential for targeted therapeutic interventions. Its ability to specifically inhibit AKR1C3, an enzyme implicated in various physiological processes and associated with diseases such as cancer, endocrine disorders, and inflammation, underscores its relevance. By modulating AKR1C3 activity, this compound may offer avenues for drug development and precision medicine approaches.

Reference

[1]. Jamieson SM, et al. 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. J Med Chem. 2012 Sep 13;55(17):7746-58.