Akt Inhibitor, Isozyme-Selective

• CAT Number: I004314
• CAS Number: 612847-09-3
• Molecular Formula: C₃₄H₂₉N₇O
• Molecular Weight: 551.65
• Purity: ≥95%
• Synonyms: 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one
• Target: Akt
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 58/210/2120 nM(Akt1/2/3)
• IUPAC Name: 3-[1-[[4-(6-phenyl-8H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one
• InChI: InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25,38H,14-17,20H2,(H,39,42)
• InChIKey: IWCQHVUQEFDRIW-UHFFFAOYSA-N
• SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=C(N=C6C=C7C(=NC=N7)C=C6N5)C8=CC=CC=C8

Isozyme-selective Akt inhibitors（Cat No.:I004314）are compounds designed to target specific isoforms of the Akt kinase, such as Akt1, Akt2, or Akt3, which play distinct roles in various cellular processes, including growth, survival, and metabolism. By selectively inhibiting a particular Akt isozyme, these inhibitors allow for precise modulation of signaling pathways, minimizing off-target effects and reducing toxicity. Isozyme-selective Akt inhibitors are valuable in cancer research, as different Akt isoforms contribute to tumorigenesis in various cancers. Their specificity enhances therapeutic potential in targeted cancer therapies and other Akt-related diseases.

Reference

[1]. Lindsley et al Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg. Med. Chem. Lett. (2005), 15(3), 761-764.
[2]. Zhong Z, Dang Y, Yuan X, Guo W, Li Y, Tan W, Cui J, Lu J, Zhang Q, Chen X, Wang Y.Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo.Cell Physiol Biochem. 2012;30(3):778-90. Epub 2012 Aug 2.