AKT Kinase Inhibitor

• CAT Number: I005042
• CAS Number: 842148-40-7
• Molecular Formula: C16H19N7O3
• Molecular Weight: 357.37
• Purity: ≥95%
• Synonyms: 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]prop-2-yn-1-ol
• InChI: InChI=1S/C16H19N7O3/c1-2-23-14-11(25-8-4-6-17)9-19-10(5-3-7-24)12(14)20-16(23)13-15(18)22-26-21-13/h9,24H,2,4,6-8,17H2,1H3,(H2,18,22)
• InChIKey: LWLOLQIXHMFYND-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

Reference

[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.