For research use only. Not for therapeutic Use.
The transduction of neurobehavioral effects by serotonin (5-<wbr></wbr>hydroxy tryptamine; 5-<wbr></wbr>HT<sub></sub>) is mediated <em>via</em> at least six major 5-<wbr></wbr>HT<sub></sub> receptor subtypes, including 5-<wbr></wbr>HT<sub>2</sub> AL 34662 is a potent 5-<wbr></wbr>HT<sub>2</sub> receptor agonist with ocular hypotensive activity. It binds to the human and rat 5-<wbr></wbr>HT<sub>2</sub> receptors in cerebral cortex homogenates with IC<sub>50</sub> values of 1.5 and 0.77 nM, respectively. AL 34662 binds to the recombinant human 5-<wbr></wbr>HT<sub>2A</sub>, 5-<wbr></wbr>HT<sub>2B</sub>, and 5-<wbr></wbr>HT<sub>2C</sub> receptors with IC<sub>50</sub> values of 14.5, 8.1, and 3 nM, respectively. In ocular hypertensive cynomolgus monkey eyes, AL 34662 lowered intraocular pressure (IOP) 25% at a dose of 100 µg and 33% at 300 µg (six hours post dose) with minimal side effects.
| Catalog Number | R040909 |
| CAS Number | 210580-75-9 |
| Synonyms | AL 34497 |
| Molecular Formula | C10H13N3O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | 1-[(2S)-2-aminopropyl]-2H-indazol-6-one |
| InChI | InChI=1S/C10H13N3O/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13/h2-5,7,12H,6,11H2,1H3/t7-/m0/s1 |
| InChIKey | CBKJGMYMAYOBDV-ZETCQYMHSA-N |
| SMILES | CC(CN1C2=CC(=O)C=CC2=CN1)N |
| Reference | 1.Sharif, N.A.,McLaughlin, M.A., and Kelly, C.R. AL-34662: A potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. Journal of Ocular Pharmacology and Therapeutics 23(1), 1-13 (2007). |
