AL 8697

• CAT Number: I011018
• CAS Number: 1057394-06-5
• Molecular Formula: C21H21F3N4O
• Molecular Weight: 402.42
• Purity: ≥95%
• Synonyms: N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide
• Target: Autophagy
• Solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
• Storage: Store at +4C
• IUPAC Name: 3-(3-tert-butyl-6,8-difluoro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide
• InChI: InChI=1S/C21H21F3N4O/c1-10-13(7-11(8-14(10)22)19(29)25-12-5-6-12)16-15(23)9-28-18(17(16)24)26-27-20(28)21(2,3)4/h7-9,12H,5-6H2,1-4H3,(H,25,29)
• InChIKey: ZVBTZTQYHOXIBC-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1C2=C(C3=NN=C(N3C=C2F)C(C)(C)C)F)C(=O)NC4CC4)F

AL 8697(CAT: I011018) is a chemical compound studied for its role as a potent inhibitor of deoxycytidine kinase (dCK), an enzyme essential for nucleotide metabolism and DNA synthesis. By inhibiting dCK, AL 8697 disrupts the activation of nucleoside analog prodrugs and interferes with cellular nucleotide pools, making it particularly valuable in oncology research. It is used to explore mechanisms of drug resistance in cancer therapies and to study the therapeutic potential of targeting dCK in malignancies reliant on elevated nucleotide synthesis. AL 8697 is a crucial tool for advancing drug discovery and understanding tumor biology.