Alantolactone

• CAT Number: I004009
• CAS Number: 546-43-0
• Molecular Formula: C15H20O2
• Molecular Weight: 232.32
• Purity: ≥95%
• Target: STAT3 inhibitor
• Solubility: 100 mM in DMSO； 100 mM in ethanol
• Storage: 3 years -20C powder

Alantolactone (CAT: I004009) is a natural sesquiterpene lactone found in various medicinal plants. It exhibits diverse pharmacological activities, including anti-inflammatory, anticancer, antimicrobial, and antioxidant properties. Alantolactone has been investigated for its potential as an anticancer agent, as it induces apoptosis and inhibits the growth of cancer cells. It also possesses anti-inflammatory properties by suppressing pro-inflammatory cytokines. Additionally, alantolactone shows antimicrobial activity against various bacteria and fungi. Although further research is needed, alantolactone holds promise as a therapeutic compound for cancer treatment, inflammation-related conditions, and infectious diseases.

Reference

[1]. Chun J, et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403.

[2]. Alzoubi K, et al. Triggering of programmed erythrocyte death by alantolactone. Toxins (Basel). 2014 Dec 22;6(12):3596-612.

[3]. Mi XG, et al. Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression. Toxicol Lett. 2014 Jan 30;224(3):349-55.

[4]. Zhang Y, et al. Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. Mol Med Rep. 2013 Oct;8(4):967-72.

[5]. Khan M, et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858.