For research use only. Not for therapeutic Use.
Alatrofloxacin Mesylate is the parental prodrug of Trovafloxacin, a broad-spectrum antibiotic.
| Catalog Number | M093915 |
| CAS Number | 157605-25-9 |
| Molecular Formula | C27H29F3N6O8S |
| Purity | ≥95% |
| Storage | Desiccate at +4C |
| IUPAC Name | 7-[(1S,5R)-6-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;methanesulfonic acid |
| InChI | InChI=1S/C26H25F3N6O5.CH4O3S/c1-10(30)24(37)31-11(2)25(38)32-20-14-7-34(8-15(14)20)23-18(29)6-13-21(36)16(26(39)40)9-35(22(13)33-23)19-4-3-12(27)5-17(19)28;1-5(2,3)4/h3-6,9-11,14-15,20H,7-8,30H2,1-2H3,(H,31,37)(H,32,38)(H,39,40);1H3,(H,2,3,4)/t10-,11-,14-,15+,20?;/m0./s1 |
| InChIKey | CYETUYYEVKNSHZ-RSUMCGCKSA-N |
| SMILES | CC(C(=O)NC(C)C(=O)NC1C2C1CN(C2)C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F)N.CS(=O)(=O)O |
| Reference | </br>1:Effects of alatrofloxacin, the parental prodrug of trovafloxacin, on phagocytic, anti-inflammatory and immunomodulation events of human THP-1 monocytes. Hall IH, Schwab UE, Ward ES, Ives TJ.Biomed Pharmacother. 2003 Oct;57(8):359-65. PMID: 14568230 </br>2:Comparison of levofloxacin, alatrofloxacin, and vancomycin for prophylaxis and treatment of experimental foreign-body-associated infection by methicillin-resistant Staphylococcus aureus. Vaudaux P, Francois P, Bisognano C, Schrenzel J, Lew DP.Antimicrob Agents Chemother. 2002 May;46(5):1503-9. PMID: 11959588 Free PMC Article</br>3:Plasma Pharmacokinetics and Tissue Penetration of Alatrofloxacin in Morbidly Obese Individuals. Pai MP, Bordley J 4th, Amsden GW.Clin Drug Investig. 2001 Mar;21(3):219-24. doi: 10.2165/00044011-200121030-00008. PMID: 27517552 </br>4:Alatrofloxacin-induced seizures during slow intravenous infusion. Melvani S, Speed BR.Ann Pharmacother. 2000 Sep;34(9):1017-9. PMID: 10981247 </br>5:Compatibility of alatrofloxacin mesylate with commonly used drugs during Y-site delivery. Voytilla KL, Rusho WJ, Tyler LS.Am J Health Syst Pharm. 2000 Aug 1;57(15):1437-9. No abstract available. PMID: 10938984 </br>6:Severe thrombocytopenia associated with alatrofloxacin. Gales BJ, Sulak LB.Ann Pharmacother. 2000 Mar;34(3):330-4. PMID: 10917380 </br>7:Pharmacokinetics of a fluoronaphthyridone, trovafloxacin (CP 99,219), in infants and children following administration of a single intravenous dose of alatrofloxacin. Bradley JS, Kearns GL, Reed MD, Capparelli EV, Vincent J.Antimicrob Agents Chemother. 2000 May;44(5):1195-9. PMID: 10770751 Free PMC Article</br>8:Stability of alatrofloxacin mesylate in 5% dextrose injection and 0.45% sodium-chloride injecion. Gupta VD, Bailey RE.Int J Pharm Compd. 2000 Jan-Feb;4(1):66-8. PMID: 23985891 </br>9:Case of vancomycin-resistant Enterococcus faecium infection associated with a transjugular intrahepatic portosystemic shunt that was treated with quinupristin/dalfopristin after bacteremia persisted with alatrofloxacin therapy. Zaman MM, Recco R, Tejwani U, Scuto TJ, Ahmed S, Hypolite A, Jayaraman G.Clin Infect Dis. 1999 Oct;29(4):954-5. No abstract available. PMID: 10589932 </br>10:[Trovan (trovafloxacin/alatrofloxacin) recalled: why? How?]. Stenver DI, Ersbøll J, Renneberg J.Ugeskr Laeger. 1999 Jul 26;161(30):4311. Danish. No abstract available. PMID: 10439701 |
