For research use only. Not for therapeutic Use.
Albiflorin（Cat No.:I003431）is a bioactive compound isolated from the roots of Paeonia albiflora, a species of peony used in traditional Chinese medicine. It belongs to the class of paeoniflorin derivatives and has been studied for its anti-inflammatory, antioxidant, and neuroprotective properties. Albiflorin is believed to exert therapeutic effects by modulating various signaling pathways, including those involved in oxidative stress and inflammatory responses. It is being investigated for its potential in treating conditions like neurodegenerative diseases, cardiovascular disorders, and inflammatory conditions, and may also have applications in promoting overall health and wellness.
| Catalog Number | I003431 |
| CAS Number | 39011-90-0 |
| Molecular Formula | C23H28O11 |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | DMSO: ≥ 5.1 mg/mL |
| Storage | -20°C |
| IUPAC Name | [(1R,3R,4R,6S,9S)-4-hydroxy-6-methyl-8-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7-oxatricyclo[4.3.0.03,9]nonan-9-yl]methyl benzoate |
| InChI | InChI=1S/C23H28O11/c1-21-8-13(25)12-7-23(21,33-19-17(28)16(27)15(26)14(9-24)32-19)22(12,20(30)34-21)10-31-18(29)11-5-3-2-4-6-11/h2-6,12-17,19,24-28H,7-10H2,1H3/t12-,13+,14+,15+,16-,17+,19-,21-,22-,23-/m0/s1 |
| InChIKey | QQUHMASGPODSIW-ICECTASOSA-N |
| SMILES | C[C@]12C[C@H]([C@@H]3C[C@]1([C@@]3(C(=O)O2)COC(=O)C4=CC=CC=C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O |
| Reference | </br>1:Anti-PTSD-like effects of albiflorin extracted from Radix paeoniae Alba. Qiu ZK, He JL, Liu X, Zeng J, Chen JS, Nie H.J Ethnopharmacol. 2017 Feb 23;198:324-330. doi: 10.1016/j.jep.2016.12.028. Epub 2016 Dec 16. PMID: 27993636 </br>2:Receptor and transporter binding and activity profiles of albiflorin extracted from Radix paeoniae Alba. Jin ZL, Gao N, Xu W, Xu P, Li S, Zheng YY, Xue M.Sci Rep. 2016 Sep 20;6:33793. doi: 10.1038/srep33793. PMID: 27646789 Free PMC Article</br>3:Albiflorin Granule significantly decreased the cholesterol gallstone formation by the regulation of insulin transduction signal. Fang BJ, Shen JY, Zhang H, Zhou S, Lyu CZ, Xie YQ.Asian Pac J Trop Med. 2016 Sep;9(9):877-81. doi: 10.1016/j.apjtm.2016.07.010. Epub 2016 Aug 4. PMID: 27633302 Free Article</br>4:Protective effects of paeoniflorin and albiflorin on chemotherapy-induced myelosuppression in mice. Zhu YL, Wang LY, Wang JX, Wang C, Wang CL, Zhao DP, Wang ZC, Zhang JJ.Chin J Nat Med. 2016 Aug;14(8):599-606. doi: 10.1016/S1875-5364(16)30070-X. PMID: 27608949 </br>5:Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Zhou J, Wang L, Wang J, Wang C, Yang Z, Wang C, Zhu Y, Zhang J.Evid Based Complement Alternat Med. 2016;2016:8082753. doi: 10.1155/2016/8082753. Epub 2016 Jun 26. PMID: 27429639 Free PMC Article</br>6:Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison. Xu W, Zhao Y, Qin Y, Ge B, Gong W, Wu Y, Li X, Zhao Y, Xu P, Xue M.Molecules. 2016 Jul 1;21(7). pii: E874. doi: 10.3390/molecules21070874. PMID: 27376264 Free Article</br>7:Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice. Zhu Y, Wang L, Yang Z, Wang J, Li W, Zhou J, Zhang J.Evid Based Complement Alternat Med. 2016;2016:5789381. doi: 10.1155/2016/5789381. Epub 2016 May 26. PMID: 27313650 Free PMC Article</br>8:Sensitive analysis and pharmacokinetic study of the isomers paeoniflorin and albiflorin after oral administration of Total Glucosides Of White Paeony Capsule in rats. Fei F, Yang H, Peng Y, Wang P, Wang S, Zhao Y, Huang J, Yu X, Feng S, Sun R, Yang N, Wang H, Aa J, Wang G.J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:30-7. doi: 10.1016/j.jchromb.2016.04.005. Epub 2016 Apr 2. PMID: 27070118 </br>9:Calcium channels contribute to albiflorin-mediated antinociceptive effects in mouse model. Zhang Y, Sun D, Meng Q, Guo W, Chen Q, Zhang Y.Neurosci Lett. 2016 Aug 15;628:105-9. doi: 10.1016/j.neulet.2016.03.054. Epub 2016 Mar 31. PMID: 27038516 </br>10:Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba. Wang YL, Wang JX, Hu XX, Chen L, Qiu ZK, Zhao N, Yu ZD, Sun SZ, Xu YY, Guo Y, Liu C, Zhang YZ, Li YF, Yu CX.J Ethnopharmacol. 2016 Feb 17;179:9-15. doi: 10.1016/j.jep.2015.12.029. Epub 2015 Dec 21. PMID: 26719283 |
