ALC-0315

• CAT Number: I021738
• CAS Number: 2036272-55-4
• Molecular Formula: C48H95NO5
• Molecular Weight: 766.29
• Purity: 98%
• Synonyms: ALC-0315; ALC 0315; ALC0315
• Solubility: Chloroform (50mg/mL) and ethanol (100mg/mL)
• Appearance: Colorless to light yellow oily liquid
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)
• InChI: InChI=1S/C48H95NO5/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)53-43-33-23-21-29-39-49(41-31-32-42-50)40-30-22-24-34-44-54-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3
• InChIKey: QGWBEETXHOVFQS-UHFFFAOYSA-N
• SMILES: OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O

ALC-0315 is a synthetic lipid used in lipid nanoparticle (LNP) formulations, particularly for mRNA-based vaccines. It is a key component in the delivery system that encapsulates mRNA, ensuring its stability and facilitating its entry into cells. ALC-0315 is essential in enabling the efficient release of mRNA into the cytoplasm, where it can be translated into proteins, such as those used in COVID-19 vaccines. Its role in enhancing mRNA delivery makes it critical in advancing mRNA-based therapeutics and vaccine development.