For research use only. Not for therapeutic Use.
Ald-Ph-amido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I017030 |
| CAS Number | 1807521-09-0 |
| Synonyms | tert-butyl 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]propanoate |
| Molecular Formula | C19H27NO6 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H27NO6/c1-19(2,3)26-17(22)8-10-24-12-13-25-11-9-20-18(23)16-6-4-15(14-21)5-7-16/h4-7,14H,8-13H2,1-3H3,(H,20,23) |
| InChIKey | UXMPBIQFYCJYBB-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCNC(=O)C1=CC=C(C=C1)C=O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
