ALDH1A3-IN-1

• CAT Number: I043876
• CAS Number: 1695970-90-1
• Molecular Formula: C13H18BrNO
• Molecular Weight: 284.19
• Purity: ≥95%
• Synonyms: 3-bromo-4-(dipropylamino)benzaldehyde
• InChI: InChI=1S/C13H18BrNO/c1-3-7-15(8-4-2)13-6-5-11(10-16)9-12(13)14/h5-6,9-10H,3-4,7-8H2,1-2H3
• InChIKey: WIBRZAPMVFXQDF-UHFFFAOYSA-N
• SMILES: CCCN(CCC)C1=C(C=C(C=C1)C=O)Br

ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer[1].
ALDH1A3-IN-1 (Compound 14) (0-200 µM, 96 h) shows antiproliferative activity in prostate cancer cell lines[1].
ALDH1A3-IN-1 (0-200 µM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner[1].

Reference

[1]. Ali I M Ibrahim, et al. Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer. J Med Chem. 2022 Mar 10;65(5):3833-3848.
 [Content Brief]