For research use only. Not for therapeutic Use.
Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).<br>Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold.<br>Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts.
| Catalog Number | A000696 |
| CAS Number | 81403-68-1 |
| Synonyms | NA |
| Molecular Formula | C19H27N5O4 • HCl |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | >19mg/mL in DMSO |
| Storage | 3 years -20C powder |
| InChIKey | YTNKWDJILNVLGX-UHFFFAOYSA-N |
