For research use only. Not for therapeutic Use.
Aliskiren（Cat No.:I002255）is a direct renin inhibitor used to manage hypertension by blocking the renin-angiotensin-aldosterone system (RAAS) at its initial step. By inhibiting renin, aliskiren decreases the production of angiotensin I and subsequently angiotensin II, a potent vasoconstrictor, leading to lower blood pressure. Unlike other RAAS-targeting drugs, aliskiren’s direct action on renin provides a unique approach to blood pressure control with minimal impact on electrolyte balance. Its effectiveness in lowering blood pressure makes aliskiren a valuable option for patients seeking alternatives to traditional antihypertensive medications.
| Catalog Number | I002255 |
| CAS Number | 173334-57-1 |
| Synonyms | (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide |
| Molecular Formula | C30H53N3O6 |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 1.5 nM |
| IUPAC Name | (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide |
| InChI | InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1 |
| InChIKey | UXOWGYHJODZGMF-QORCZRPOSA-N |
| SMILES | CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N |
| Reference | 1: Zheng SL, Roddick AJ, Ayis S. Effects of aliskiren on mortality, 2: Nadeem S, Batisky DL. Aliskiren, the first direct renin inhibitor: assessing a 3: Friedrich S, Schmieder RE. Review of direct renin inhibition by aliskiren. J <br> |
