ALK2-IN-2

• CAT Number: I019091
• CAS Number: 2254409-25-9
• Molecular Formula: C₂₈H₂₇N₅O₂S
• Molecular Weight: 497.61
• Purity: ≥95%
• Target: TGF-β Receptor
• IUPAC Name: 4-[6-[4-(1-pyrrolidin-1-ylethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide
• InChI: InChI=1S/C28H27N5O2S/c1-19(32-14-4-5-15-32)20-8-10-21(11-9-20)22-16-30-28-26(17-31-33(28)18-22)24-12-13-27(36(29,34)35)25-7-3-2-6-23(24)25/h2-3,6-13,16-19H,4-5,14-15H2,1H3,(H2,29,34,35)
• InChIKey: IPESYYFOXATSFJ-UHFFFAOYSA-N
• SMILES: CC(C1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=C(C5=CC=CC=C54)S(=O)(=O)N)N=C2)N6CCCC6

ALK2-IN-2 (Cat.No:I019091), also known as Compound 10, is a selective inhibitor of the ALK2 receptor tyrosine kinase, which plays a role in bone formation and repair. It has shown potential as a treatment for fibrodysplasia ossificans progressiva, a rare genetic disorder characterized by abnormal bone formation. 

Reference

[1]. Jiang JK, et al. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3356-3362.