For research use only. Not for therapeutic Use.
ALK4290 (AKST4290) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3[1]. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism[2][3].
| Catalog Number | I030568 |
| CAS Number | 1251528-23-0 |
| Synonyms | 2-[[(2R)-1-[1-[(4-chloro-3-methylphenyl)methyl]piperidin-4-yl]-5-oxopyrrolidine-2-carbonyl]amino]-N,N,6-trimethylpyridine-4-carboxamide |
| Molecular Formula | C27H34ClN5O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H34ClN5O3/c1-17-13-19(5-6-22(17)28)16-32-11-9-21(10-12-32)33-23(7-8-25(33)34)26(35)30-24-15-20(14-18(2)29-24)27(36)31(3)4/h5-6,13-15,21,23H,7-12,16H2,1-4H3,(H,29,30,35)/t23-/m1/s1 |
| InChIKey | DWKNOLCXIFYNFV-HSZRJFAPSA-N |
| SMILES | CC1=CC(=CC(=N1)NC(=O)C2CCC(=O)N2C3CCN(CC3)CC4=CC(=C(C=C4)Cl)C)C(=O)N(C)C |
| Reference | [1]. NIVENS MC, et, al. Use of ccr3-inhibitors. US20130261153A1. [2]. Samanta A, te, al. Emerging Therapies in Neovascular Age-Related Macular Degeneration in 2020. Asia Pac J Ophthalmol (Phila). May-Jun 2020; 9(3):250-259. [3]. Clinical Development of AKST4290 as a Novel Parkinson’s Therapeutic |
