For research use only. Not for therapeutic Use.
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1)[1].
| Catalog Number | I044068 |
| CAS Number | 2705900-81-6 |
| Synonyms | ethyl 5-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxylate |
| Molecular Formula | C19H15FN4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H15FN4O2/c1-2-26-19(25)16-11-22-24-8-7-13(9-17(16)24)15-10-21-23-18(15)12-3-5-14(20)6-4-12/h3-11H,2H2,1H3,(H,21,23) |
| InChIKey | GFFVSPZTWRNCIU-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C2C=C(C=CN2N=C1)C3=C(NN=C3)C4=CC=C(C=C4)F |
| Reference | [1]. Zhiyong Yu, et al. Transforming growth factor-beta receptor inhibitor. Patent WO2021190425A1. |
