all-trans 4-Keto Retinoic Acid

• CAT Number: R005702
• CAS Number: 38030-57-8
• Molecular Formula: C20H26O3
• Molecular Weight: 314.425
• Purity: ≥95%
• Synonyms: 4-Oxoretinoic Acid; 4-Ketoretinoic Acid; 4-Oxo-all-trans-retinoic acid; 4-Oxo-atRA; 4-Oxotretinoin; 4-keto-Retinoic Acid; Ro 11-4824; Ro 12-4824; all-trans-4-Oxoretinoic Acid
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
• InChI: InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+
• InChIKey: GGCUJPCCTQNTJF-FRCNGJHJSA-N
• SMILES: CC1=C(C(CCC1=O)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

All-trans 4-Keto Retinoic Acid is a metabolite of retinoic acid, which is a derivative of vitamin A. This compound is involved in the regulation of gene expression, influencing processes like cell differentiation, growth, and apoptosis. Retinoic acids, including 4-keto retinoic acid, play crucial roles in embryonic development, immune function, and skin health. The “all-trans” configuration refers to the linear arrangement of its double bonds, which is important for its biological activity. Research on this compound focuses on its potential therapeutic applications in dermatology, oncology, and developmental biology, where retinoic acids are known to modulate critical cellular pathways.