For research use only. Not for therapeutic Use.
Heneicosapentaenoic Acid (HPA) is a 21:5 ω-<wbr></wbr>3 fatty acid present in trace amounts in the green alga <em>B. pennata</em> and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the Δ HPA can be used to study the significance of the position of the double bonds in ω-<wbr></wbr>3 fatty acids. It incorporates into phospholipids and into triacylglycerol <em>in vivo</em> with the same efficiency as EPA and docosahexaenoic acid and exhibits strong inhibition of arachidonic acid synthesis from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-<wbr></wbr>lipoxygenase but retains the ability to rapidly inactivate PGHS.
| CAS Number | 24257-10-1 |
| Synonyms | (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-Heneicosapentaenoic Acid; |
| Molecular Formula | C21H32O2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (6Z,9Z,12Z,15Z,18Z)-henicosa-6,9,12,15,18-pentaenoic acid |
| InChI | InChI=1S/C21H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21(22)23/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-20H2,1H3,(H,22,23)/b4-3-,7-6-,10-9-,13-12-,16-15- |
| InChIKey | OQOCQFSPEWCSDO-JLNKQSITSA-N |
| SMILES | CCC=CCC=CCC=CCC=CCC=CCCCCC(=O)O |
