Allicin

• CAT Number: R054984
• CAS Number: 539-86-6
• Molecular Formula: C6H10OS2
• Molecular Weight: 162.27
• Purity: ≥95%
• Synonyms: 2-Propene-1-sulfinothioic Acid S-2-Propen-1-yl Ester; Allicin; Allimed; Alliosan; Allisure Liquid; Diallyl Thiosulfinate; Thio-2-propene-1-sulfinic Acid S-Allyl Ester
• Target: Bacterial
• Storage: -80°C
• IUPAC Name: 3-prop-2-enylsulfinylsulfanylprop-1-ene
• InChI: InChI=1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2
• InChIKey: JDLKFOPOAOFWQN-UHFFFAOYSA-N
• SMILES: C=CCSS(=O)CC=C

Allicin (Cat No.:R054984) is the active sulfur-containing compound derived from garlic, known for its potent antimicrobial, antioxidant, and anti-inflammatory properties. Recognized for its broad-spectrum efficacy, Allicin is used in studies targeting bacterial, fungal, and viral pathogens, as well as in cardiovascular and cancer research. Its mechanism involves disrupting microbial cell membranes and inhibiting enzyme activity, contributing to its effectiveness in fighting infections. Allicin’s potential therapeutic applications extend to supporting immune health and reducing oxidative stress, making it valuable in both pharmacological research and nutraceuticals focused on health and wellness.

Reference

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2: Zhong J, Xian D, Xiong X, Liu J. Therapeutic Hotline. Oral allicin in the treatment of Behcet/'s disease through attenuating oxidative stress: A pilot study in 20 patients with mucocutaneous lesions. Dermatol Ther. 2017 Jan;30(1). doi: 10.1111/dth.12429. Epub 2016 Oct 9. PubMed PMID: 27723197.
3: Li S, Chen S, Yang W, Liao L, Li S, Li J, Zheng Y, Zhu D. Allicin relaxes isolated mesenteric arteries through activation of PKA-K(ATP) channel in rat. J Recept Signal Transduct Res. 2017 Feb;37(1):17-24. doi: 10.3109/10799893.2016.1155065. Epub 2016 Apr 6. PubMed PMID: 27049346.
4: Panyod S, Wu WK, Ho CT, Lu KH, Liu CT, Chu YL, Lai YS, Chen WC, Lin YE, Lin SH, Sheen LY. Diet Supplementation with Allicin Protects against Alcoholic Fatty Liver Disease in Mice by Improving Anti-inflammation and Antioxidative Functions. J Agric Food Chem. 2016 Sep 28;64(38):7104-13. doi: 10.1021/acs.jafc.6b02763. Epub 2016 Sep 19. PubMed PMID: 27584700.
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13: Lin JJ, Chang T, Cai WK, Zhang Z, Yang YX, Sun C, Li ZY, Li WX. Post-injury administration of allicin attenuates ischemic brain injury through sphingosine kinase 2: In vivo and in vitro studies. Neurochem Int. 2015 Oct;89:92-100. doi: 10.1016/j.neuint.2015.07.022. Epub 2015 Aug 12. PubMed PMID: 26275594.
14: Wang H, Li X, Liu X, Shen D, Qiu Y, Zhang X, Song J. Influence of pH, concentration and light on stability of allicin in garlic (Allium sativum L.) aqueous extract as measured by UPLC. J Sci Food Agric. 2015 Jul;95(9):1838-44. doi: 10.1002/jsfa.6884. Epub 2014 Sep 25. PubMed PMID: 25205359.
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16: Wu X, Li X, Song Y, Li H, Bai X, Liu W, Han Y, Xu L, Li J, Zhang D, Wang H, Fan Z. Allicin protects auditory hair cells and spiral ganglion neurons from cisplatin – Induced apoptosis. Neuropharmacology. 2017 Apr;116:429-440. doi: 10.1016/j.neuropharm.2017.01.001. Epub 2017 Jan 3. PubMed PMID: 28062185.
17: Ranjbar-Omid M, Arzanlou M, Amani M, Shokri Al-Hashem SK, Amir Mozafari N, Peeri Doghaheh H. Allicin from garlic inhibits the biofilm formation and urease activity of Proteus mirabilis in vitro. FEMS Microbiol Lett. 2015 May;362(9). pii: fnv049. doi: 10.1093/femsle/fnv049. Epub 2015 Apr 2. PubMed PMID: 25837813.
18: Zhuang J, Li Y, Chi Y. Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells. Anticancer Drugs. 2016 Apr;27(4):312-7. doi: 10.1097/CAD.0000000000000340. PubMed PMID: 26771864.
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20: Gruhlke MC, Hemmis B, Noll U, Wagner R, Lühring H, Slusarenko AJ. The defense substance allicin from garlic permeabilizes membranes of Beta vulgaris, Rhoeo discolor, Chara corallina and artificial lipid bilayers. Biochim Biophys Acta. 2015 Apr;1850(4):602-11. doi: 10.1016/j.bbagen.2014.11.020. Epub 2014 Dec 4. PubMed PMID: 25484312.