For research use only. Not for therapeutic Use.
Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities[1][2].
Alliin (0-160 μM, 2 h) reduces lipid accumulation and ameliorates the cAMP Levels in 1,3-DCP-induced HepG2 cells[1].
Alliin (0-160 μM, 23 h) inhibits the expression levels of proteins and genes (SREBP-1, FAS, SREBP-2 and HMGCR) involved in AMPK–SREBPs signaling pathway in HepG2 Cells[1].
Alliin (100 μM, 6 h) inhibits p38, JNK and ERK1/2 phosphorylation and blocks MAPKs-mediated NF-κB/AP-1/STAT-1 signal transducer to improve the inflammatory responses in LPS-stimulated RAW264.7 cells[2].
Alliin (500 mg/kg, i.g., 10 days) ameliorates colon damage and spleen changes in DSS colitis mouse model through reduces pro-inflammatory cytokines (iNOS, TNF-α and IL-6) expression and inhibits the phosphorylation of ERK1/2, JNK, p38 and PPARγ[2].
| Catalog Number | R021596 |
| CAS Number | 556-27-4 |
| Synonyms | (2R)-2-amino-3-[(S)-prop-2-enylsulfinyl]propanoic acid |
| Molecular Formula | C6H11NO3S |
| Purity | ≥95% |
| InChI | InChI=1S/C6H11NO3S/c1-2-3-11(10)4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-,11-/m0/s1 |
| InChIKey | XUHLIQGRKRUKPH-DYEAUMGKSA-N |
| SMILES | C=CCS(=O)CC(C(=O)O)N |
| Reference | [1]. Lu J, et al. Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. Life Sci. 2018 Feb 15;195:19-24. [2]. Shi L, et al. Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation. Mol Nutr Food Res. 2017 Sep;61(9). |
