For research use only. Not for therapeutic Use.
Allitinib (Cat No.: I001767) is an irreversible tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR) and HER2, both of which are implicated in the progression of various cancers. By covalently binding to the kinase domains, Allitinib effectively blocks downstream signaling pathways involved in cell proliferation and survival. It demonstrates potent antitumor activity, including efficacy against EGFR mutations resistant to first-generation inhibitors. Allitinib is under investigation for treating cancers such as non-small cell lung cancer and breast cancer, offering promise in targeted cancer therapy.
| CAS Number | 897383-62-9 (free base) |
| Synonyms | AST1306; AST-1306; AST 1306; ALS1306; ALS-1306; ALS1306; AST 6; AST-6; AST6. Allitinib;N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide |
| Molecular Formula | C24H18ClFN4O2 |
| Purity | ≥95% |
| Target | ErbB2 and EGFR inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months). |
| InChI | InChI=1S/C24H18ClFN4O2/c1-2-23(31)29-17-6-8-21-19(11-17)24(28-14-27-21)30-18-7-9-22(20(25)12-18)32-13-15-4-3-5-16(26)10-15/h2-12,14H,1,13H2,(H,29,31)(H,27,28,30) |
| InChIKey | MVZGYPSXNDCANY-UHFFFAOYSA-N |
| SMILES | C=CC(NC1=CC2=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)N=CN=C2C=C1)=O |
| Reference | </br>1:Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker. Silva-Oliveira RJ, Silva VA, Martinho O, Cruvinel-Carloni A, Melendez ME, Rosa MN, de Paula FE, de Souza Viana L, Carvalho AL, Reis RM.Cell Oncol (Dordr). 2016 Jun;39(3):253-63. doi: 10.1007/s13402-016-0270-z. Epub 2016 Feb 26. PMID: 26920031 </br>2:Metabolism and pharmacokinetics of allitinib in cancer patients: the roles of cytochrome P450s and epoxide hydrolase in its biotransformation. Lin L, Xie C, Gao Z, Chen X, Zhong D.Drug Metab Dispos. 2014 May;42(5):872-84. doi: 10.1124/dmd.113.056341. Epub 2014 Mar 5. PMID: 24598282 Free Article</br>3:Development and validation of a sensitive LC-MS/MS assay for the simultaneous quantification of allitinib and its two metabolites in human plasma. Lin L, Gao Z, Chen X, Zhong D.J Pharm Biomed Anal. 2013 Dec;86:49-55. doi: 10.1016/j.jpba.2013.07.003. Epub 2013 Jul 19. PMID: 23973791 |
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