ALLO-2

• CAT Number: I012835
• CAS Number: 1357350-60-7
• Molecular Formula: C18H12F3N5O
• Molecular Weight: 371.32
• Purity: ≥95%
• Synonyms: (1H-Indazol-5-yl)-[4-(4-trifluoromethoxy-phenyl)-pyrimidin-2-yl]-amine; N-[4-[4-(Trifluoromethoxy)phenyl]-2-pyrimidinyl]-1H-indazol-5-amine
• Target: Smo
• Storage: Store at -20°C
• IUPAC Name: N-[4-[4-(trifluoromethoxy)phenyl]pyrimidin-2-yl]-1H-indazol-5-amine
• InChI: InChI=1S/C18H12F3N5O/c19-18(20,21)27-14-4-1-11(2-5-14)15-7-8-22-17(25-15)24-13-3-6-16-12(9-13)10-23-26-16/h1-10H,(H,23,26)(H,22,24,25)
• InChIKey: QTYGEBIJNWMVCW-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=NC(=NC=C2)NC3=CC4=C(C=C3)NN=C4)OC(F)(F)F

ALLO-2（Cat No.: I012835）, stands as a potent antagonist specifically designed to target Smoothened (Smo) receptor-resistant mutants. It demonstrates remarkable efficacy by inhibiting luciferase expression induced by the Smo agonist Hh-Ag1.5 in TM3-Gli-Luc cells with an impressive IC50 of 6 nM. This attribute positions ALLO-2 as a promising tool in the study of Hedgehog signaling pathways and may hold potential in therapeutic research for conditions related to aberrant Hedgehog signaling, such as certain cancers.