For research use only. Not for therapeutic Use.
Alloxan tetrahydrate (CAT: I021793) is an acidic compound resulting from the oxidation of uric acid. This compound is known for its ability to induce diabetes in experimental animals by damaging insulin-producing pancreatic beta cells. Alloxan selectively targets these cells due to their high sensitivity to oxidative stress, resulting in a reduction in insulin secretion and the development of diabetes-like symptoms. Its application in inducing diabetes in research models underscores its importance in the study of diabetes pathogenesis and potential therapeutic interventions.
| Catalog Number | I021793 |
| CAS Number | 6010-91-9 |
| Synonyms | Alloxan tetrahydrate; Mesoxalylurea tetrahydrate |
| Molecular Formula | C4H10N2O8 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-dihydroxy-, hydrate (1:3) |
| InChI | InChI=1S/C4H4N2O5.3H2O/c7-1-4(10,11)2(8)6-3(9)5-1;;;/h10-11H,(H2,5,6,7,8,9);3*1H2 |
| InChIKey | PBPLAJFENFYAFN-UHFFFAOYSA-N |
| SMILES | O.O.O.OC1(O)C(=O)NC(=O)NC1=O |
| Reference | 1: Lin H, Zheng M, Mao X, Feng X, Li J, Rao G, Lin F. Oxytocin treatment prevents marrow adiposity observed in alloxan-induced diabetic rabbits using proton MR spectroscopy. Endokrynol Pol. 2018 Jun 28. doi: 10.5603/EP.a2018.0040. [Epub ahead of print] PubMed PMID: 29952410. |
