For research use only. Not for therapeutic Use.
Almonertinib mesylate（Cat No.:I028890）is a targeted therapy used in the treatment of non-small cell lung cancer (NSCLC) with specific mutations in the epidermal growth factor receptor (EGFR). It is an irreversible EGFR tyrosine kinase inhibitor that selectively binds to and inhibits mutated forms of EGFR, preventing cancer cell growth and proliferation. Almonertinib mesylate has shown effectiveness in patients with EGFR T790M mutations, which are often associated with resistance to first-generation EGFR inhibitors. By overcoming this resistance, it offers a promising option for improving outcomes in EGFR-mutant NSCLC patients.
| CAS Number | 2134096-06-1 |
| Synonyms | N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide;methanesulfonic acid |
| Molecular Formula | C31H39N7O5S |
| Purity | ≥95% |
| IUPAC Name | N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide;methanesulfonic acid |
| InChI | InChI=1S/C30H35N7O2.CH4O3S/c1-6-29(38)32-24-17-25(28(39-5)18-27(24)36(4)16-15-35(2)3)34-30-31-14-13-23(33-30)22-19-37(20-11-12-20)26-10-8-7-9-21(22)26;1-5(2,3)4/h6-10,13-14,17-20H,1,11-12,15-16H2,2-5H3,(H,32,38)(H,31,33,34);1H3,(H,2,3,4) |
| InChIKey | WTEXJDGTVUQRQY-UHFFFAOYSA-N |
| SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.CS(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
