Aloe emodin anthrone

• CAT Number: I021806
• CAS Number: 6247-99-0
• Molecular Formula: C15H12O4
• Molecular Weight: 256.26
• Purity: 98%
• Synonyms: Aloe emodin anthrone
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 9(10H)-Anthracenone, 1,8-dihydroxy-3-(hydroxymethyl)-
• InChI: 1S/C15H12O4/c16-7-8-4-10-6-9-2-1-3-11(17)13(9)15(19)14(10)12(18)5-8/h1-5,16-18H,6-7H2
• InChIKey: AVZIASIVCYCZND-UHFFFAOYSA-N
• SMILES: C1(c2c(cc(cc2O)CO)Cc2c1c(O)ccc2)=O

Aloe emodin anthrone is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.

Reference

1: Kai M, Hayashi K, Kaida I, Aki H, Yamamoto M. Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa. Biol Pharm Bull. 2002 Dec;25(12):1608-13. PubMed PMID: 12499649.
2: Yagi T, Yamauchi K, Kuwano S. The synergistic purgative action of aloe-emodin anthrone and rhein anthrone in mice: synergism in large intestinal propulsion and water secretion. J Pharm Pharmacol. 1997 Jan;49(1):22-5. PubMed PMID: 9120764.
3: Che QM, Akao T, Hattori M, Kobashi K, Namba T. Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone. Planta Med. 1991 Feb;57(1):15-9. PubMed PMID: 2062951.