Aloin

• CAT Number: I001592
• CAS Number: 1415-73-2
• Molecular Formula: C21H22O9
• Molecular Weight: 418.40
• Purity: ≥95%
• Synonyms: Barbaloin;NSC 407305
• Target: Disease Research Fields
• Solubility: DMSO: 27 mg/mL
• Storage: 2-8°C
• IUPAC Name: (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
• InChI: InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14+,17-,19+,20-,21+/m1/s1
• InChIKey: AFHJQYHRLPMKHU-OSYMLPPYSA-N
• SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C([C@H]2[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C(C=C3O)CO

Aloin（Cat No.:I001592）is a natural anthraquinone glycoside primarily derived from Aloe species, known for its strong laxative and purgative properties. When ingested, aloin is metabolized by gut bacteria into active compounds that stimulate bowel movements, making it effective for short-term constipation relief. Beyond its gastrointestinal effects, aloin has been studied for its antioxidant, anti-inflammatory, and antimicrobial activities, contributing to its use in traditional medicine and skincare. However, due to its potency, aloin should be used with caution, as prolonged use can lead to dependency and potential side effects.

Reference

[1]. Pan Q, et al. Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int. 2013 Jul 12;13(1):69.

[2]. Tabolacci C, et al. Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids. 2013 Jan;44(1):293-300.

[3]. Cui Y, et al. Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice. Arch Pharm Res. 2014 Dec;37(12):1624-33.