For research use only. Not for therapeutic Use.
ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1].
| Catalog Number | I043907 |
| CAS Number | 2764818-23-5 |
| Synonyms | octyl N-[[3-(1H-indol-2-yl)phenyl]sulfamoyl]carbamate |
| Molecular Formula | C23H29N3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C23H29N3O4S/c1-2-3-4-5-6-9-15-30-23(27)26-31(28,29)25-20-13-10-12-18(16-20)22-17-19-11-7-8-14-21(19)24-22/h7-8,10-14,16-17,24-25H,2-6,9,15H2,1H3,(H,26,27) |
| InChIKey | LKGGPLHYSWLQPL-UHFFFAOYSA-N |
| SMILES | CCCCCCCCOC(=O)NS(=O)(=O)NC1=CC=CC(=C1)C2=CC3=CC=CC=C3N2 |
| Reference | [1]. Golovanov A, et al. N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65(3):1979-1995. |
