ALP/Carbonic anhydrase-IN-1

• CAT Number: I040519
• CAS Number: 2091887-74-8
• Molecular Formula: C15H16N2
• Molecular Weight: 224.30
• Purity: ≥95%
• Synonyms: 6-butylpyrrolo[1,2-a][1,8]naphthyridine
• InChI: InChI=1S/C15H16N2/c1-2-3-6-12-11-13-7-4-9-16-15(13)17-10-5-8-14(12)17/h4-5,7-11H,2-3,6H2,1H3
• InChIKey: MIQCJJMJHXDYPK-UHFFFAOYSA-N
• SMILES: CCCCC1=CC2=C(N=CC=C2)N3C1=CC=C3

ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC50 values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively[1].

Reference

[1]. Salman Alrokayan, et al. [1, 8]-Naphthyridine derivatives as dual inhibitor of alkaline phosphatase and carbonic anhydrase. BMC Chem. 2023 Oct 25;17(1):142.
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