For research use only. Not for therapeutic Use.
Alpha-Casozepine (CAT: I021815) is a bioactive peptide derived from casein, a milk protein. It exhibits pharmacological activity as a natural anxiolytic agent by selectively binding to the benzodiazepine receptors in the central nervous system, thereby modulating the GABAergic neurotransmission. This interaction results in anxiolytic effects, promoting relaxation and reducing anxiety symptoms. Alpha-Casozepine has been studied for its potential application in the treatment of anxiety-related disorders in both humans and animals. It represents a promising natural alternative for managing anxiety, offering potential benefits in the field of mental health and well-being.
| Catalog Number | I021815 |
| CAS Number | 117592-45-7 |
| Synonyms | alpha-Casozepine; Lactium; |
| Molecular Formula | C60H94N14O16 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (2S,5S,8S,11S,14S)-11-(3-amino-3-oxopropyl)-14-((2S,5S,11S,14S)-14-amino-5-(4-hydroxybenzyl)-15-(4-hydroxyphenyl)-2,11-diisobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecanamido)-2-(3-guanidinopropyl)-5,8-diisobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecanedioic acid |
| InChI | InChI=1S/C60H94N14O16/c1-31(2)24-43(71-51(81)39(61)28-35-11-15-37(75)16-12-35)52(82)66-30-49(78)67-47(29-36-13-17-38(76)18-14-36)58(88)74-44(25-32(3)4)55(85)69-41(20-22-50(79)80)53(83)68-40(19-21-48(62)77)54(84)72-46(27-34(7)8)57(87)73-45(26-33(5)6)56(86)70-42(59(89)90)10-9-23-65-60(63)64/h11-18,31-34,39-47,75-76H,9-10,19-30,61H2,1-8H3,(H2,62,77)(H,66,82)(H,67,78)(H,68,83)(H,69,85)(H,70,86)(H,71,81)(H,72,84)(H,73,87)(H,74,88)(H,79,80)(H,89,90)(H4,63,64,65)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 |
| InChIKey | SKGURMFKEAFAGD-CSYZDTNESA-N |
| SMILES | CC(C[C@@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)Cc1ccc(O)cc1)=O)=O)NC([C@H](Cc2ccc(O)cc2)N)=O)C |
| Reference | 1: Miclo L, Perrin E, Driou A, Papadopoulos V, Boujrad N, Vanderesse R, Boudier JF, Desor D, Linden G, Gaillard JL. Characterization of alpha-casozepine, a tryptic peptide from bovine alpha(s1)-casein with benzodiazepine-like activity. FASEB J. 2001 Aug;15(10):1780-2. PubMed PMID: 11481228. |
