ALPHA-MANNOSIDASE

• CAT Number: M004135
• CAS Number: 9025-42-7
• Molecular Formula: Zn+2
• Molecular Weight: 65.38
• Purity: ≥95%
• Synonyms: ALPHA-MANNOSIDASE;ALPHA-D-MANNOSIDE MANNOHYDROLASE;ALPHA1,6-MANNOSIDASE;ALPHA1-2,3-MANNOSIDASE;EC 3.2.1.24;a1,2-Mannoisdase, Trichodermareesei, Recomb., Saccharomyces;a1,6-Mannosidase, Xanthomonassp., Recomb., E. coli;a1-2,3-Mannosidase, Recomb., E.
• Storage: -20°C
• IUPAC Name: zinc(2+)
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES: [Zn+2]

ALPHA-MANNOSIDASE (CAS 9025-42-7) is an exo-glycosidase and an inc metalloenzyme. It has been shown to inhibit the proliferation of B-lymphocytes. It can be used to liberate mannose from a variety of synthetic and natural α-mannosides. It has also been used in a study to investigate the causes of neurodegeneration in mucolipidosis II ′knock-in′ mice.

 

Reference

1.Kollmann, K., et al. "Lysosomal dysfunction causes neurodegeneration in mucolipidosis II ‘knock-in’mice." Brain 135.9 (2012): 2661-2675.
2.EINHOFF, Wolfgang, and Harold RÜDIGER. "The α-mannosidase from Canavalia ensiformis seeds: Chemical and kinetic properties and action on animal Lymphocytes." Biological Chemistry Hoppe-Seyler 369.1 (1988): 165-170.
3.Kumar, Gnanesh, et al. "Jack bean α-mannosidase: Amino acid sequencing and N-glycosylation analysis of a valuable glycomics tool." Glycobiology 24.3 (2014).
5.Nemčovičová, I., et al. "Expression, purification and preliminary crystallographic analysis of Drosophila melanogaster lysosomal α-mannosidase." Acta Crystallographica Section F: Structural Biology and Crystallization Communications 68.8 (2012): 965-970.