For research use only. Not for therapeutic Use.
ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1 is an intracytoplasmic serine threonine protein kinase that plays an important role in activating the innate immune response to bacteria via TRAF-interacting protein with forkhead-associated domain (TIFA) dependent proinflammatory NF-κB signaling[1].
| Catalog Number | I043511 |
| CAS Number | 2765457-72-3 |
| Synonyms | 1-[4-[2-(4-methoxyphenyl)propan-2-yl]-1,3-thiazol-2-yl]-3-[1-(6-piperazin-1-ylpyridin-3-yl)ethyl]urea |
| Molecular Formula | C25H32N6O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H32N6O2S/c1-17(18-5-10-22(27-15-18)31-13-11-26-12-14-31)28-23(32)30-24-29-21(16-34-24)25(2,3)19-6-8-20(33-4)9-7-19/h5-10,15-17,26H,11-14H2,1-4H3,(H2,28,29,30,32) |
| InChIKey | JWNGYFWRZVKHOW-UHFFFAOYSA-N |
| SMILES | CC(C1=CN=C(C=C1)N2CCNCC2)NC(=O)NC3=NC(=CS3)C(C)(C)C4=CC=C(C=C4)OC |
| Reference | [1]. Danyang Liu, et al. Alpha protein kinase 1 inhibitors and methods of use. WO2022063152A1. |
