For research use only. Not for therapeutic Use.
ALPK1-IN-2 (compound T001) is a potent ALPK1 (alpha-kinase 1) inhibitor, with an IC50 of 95 nM. ALPK1-IN-2 also inhibits NF-κB, with an IC50 of 1.31 μM[1].
| Catalog Number | I043660 |
| CAS Number | 2765633-68-7 |
| Synonyms | 4-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-2,6-difluoro-N-(4-methoxy-1,3-benzothiazol-2-yl)benzamide |
| Molecular Formula | C20H18F2N4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H18F2N4O2S/c1-28-15-3-2-4-16-18(15)24-20(29-16)25-19(27)17-13(21)6-12(7-14(17)22)26-8-10-5-11(9-26)23-10/h2-4,6-7,10-11,23H,5,8-9H2,1H3,(H,24,25,27) |
| InChIKey | SHSJEVPKHXWBHO-UHFFFAOYSA-N |
| SMILES | COC1=C2C(=CC=C1)SC(=N2)NC(=O)C3=C(C=C(C=C3F)N4CC5CC(C4)N5)F |
| Reference | [1]. Danyang Liu, et al. Benzothiazole and quinoline derivatives and their use. WO2022063153A1. |
