ALS-8112

• CAT Number: I001710
• CAS Number: 1445379-92-9
• Molecular Formula: C10H13ClFN3O4
• Molecular Weight: 293.68
• Purity: ≥95%
• Target: RSV
• Solubility: DMSO: ＞ 47 mg/mL
• Storage: Store at -20°C
• IC50: 0.15 μM (EC50)
• IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• InChI: InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1
• InChIKey: AWSRKKBIPSQHOJ-IBCQBUCCSA-N
• SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@](O2)(CO)CCl)O)F

ALS-8112（Cat No.:I001710）is a novel nucleoside analog with potent antiviral activity, primarily studied for its effectiveness against respiratory syncytial virus (RSV). It acts by inhibiting the viral RNA polymerase, disrupting RNA synthesis and viral replication. ALS-8112 has demonstrated high selectivity and efficacy in preclinical studies, making it a valuable tool for understanding RSV replication mechanisms and evaluating antiviral drug candidates. Its unique properties contribute to research on RNA viruses and the development of targeted therapies, addressing significant unmet needs in respiratory viral infection management.

Reference

[1]. Clarke MO, et al. Discovery of β-D-2/’-deoxy-2/’-α-fluoro-4/’-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2484-7.
[2]. Wang G, et al. Discovery of 4/’-chloromethyl-2/’-deoxy-3/’,5/’-di-O-isobutyryl-2/’-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78.