ALS-8112

• CAT Number: I001710
• CAS Number: 1445379-92-9
• Molecular Formula: C10H13ClFN3O4
• Molecular Weight: 293.68
• Purity: ≥95%
• Target: RSV
• Solubility: DMSO: ＞ 47 mg/mL
• Storage: Store at -20°C
• IC50: 0.15 μM (EC50) [2]
• IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• InChI: InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1
• InChIKey: AWSRKKBIPSQHOJ-IBCQBUCCSA-N
• SMILES: OC[C@]1(CCl)[C@H]([C@@H](F)[C@H](N2C(N=C(C=C2)N)=O)O1)O

ALS-8112 (Cat.No:I001710), also known as tirabrutinib, is a reversible, orally available Bruton’s tyrosine kinase (BTK) inhibitor. It is used for the treatment of B-cell malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). ALS-8112 blocks BTK activity, which is involved in the activation of B-cells and their proliferation, ultimately leading to apoptosis of cancerous cells.

Reference

[1]. Clarke MO, et al. Discovery of β-D-2/’-deoxy-2/’-α-fluoro-4/’-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2484-7.
[2]. Wang G, et al. Discovery of 4/’-chloromethyl-2/’-deoxy-3/’,5/’-di-O-isobutyryl-2/’-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78.