For research use only. Not for therapeutic Use.
Althiazide (Cat.No:R048093) is a thiazide diuretic, commonly prescribed to manage hypertension and edema. It works by promoting diuresis, reducing excess fluid in the body. Althiazide’s mechanism involves inhibiting sodium reabsorption in the distal tubules of the kidneys, leading to increased urine production and decreased blood volume.
| Catalog Number | R048093 |
| CAS Number | 5588-16-9 |
| Synonyms | 6-Chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; 3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; Althizide; Altizid; Altizide; |
| Molecular Formula | C11H14ClN3O4S3 |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-1$l^{6} |
| InChI | InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17) |
| InChIKey | VGLGVJVUHYTIIU-UHFFFAOYSA-N |
| SMILES | C=CCSCC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl |
| Reference | </br>1:[Acute necrotic pancreatitis and althiazide]. Charneau J, Mendler M.Gastroenterol Clin Biol. 1997;21(2):164-5. French. No abstract available. PMID: 9161489 </br>2:[Interstitial pneumopathy in a woman treated with althiazide]. Clarke JP, Germaud P.Rev Pneumol Clin. 1994;50(4):165-7. French. PMID: 7724984 </br>3:[Pharmacokinetics in healthy subjects of althiazide and spironolactone in a fixed combination for 2 doses]. Doignon JL, Grognet JM, Thébault JJ, Caplain M, Capron MH, Pelletier B, Wehrlen M, Istin M.Therapie. 1990 Nov-Dec;45(6):475-81. French. PMID: 2080486 </br>4:Simultaneous determination of althiazide and spironolactone in tablets by high-performance liquid chromatography. De Croo F, Van den Bossche W, De Moerloose P.J Chromatogr. 1985 Jul 26;329(3):422-7. No abstract available. PMID: 4044727 </br>5:Evaluation of a spironolactone and althiazide combination (aldactacine) in Africans with benign essential hypertension. Pinto JM.East Afr Med J. 1981 Jan;58(1):44-50. No abstract available. PMID: 7011783 </br>6:The use of a spironolactone and althiazide combination (aldactacine) in the treatment of benign essential hypertension. Mngola EN.J Int Med Res. 1980;8(3):199-204. PMID: 6993252 |
