Altretamine

• CAT Number: A000197
• CAS Number: 645-05-6
• Molecular Formula: C9H18N6
• Molecular Weight: 210.28
• Purity: ≥95%
• Synonyms: Hexamethylmelamine, NSC13875, ENT50852; Hexalen; 645-05-6; Hexastat; Hemel
• Target: DNA Alkylator/Crosslinker
• Solubility: >8.85mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
• InChIKey: UUVWYPNAQBNQJQ-UHFFFAOYSA-N
• SMILES: CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C

Altretamine is a synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. Check for active clinical trials or closed clinical trials using this agent.

Reference

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