Alvameline maleate

• CAT Number: I021867
• CAS Number: 219581-36-9
• Molecular Formula: C13H19N5O4
• Molecular Weight: 309.33
• Purity: 98%
• Synonyms: Alvameline maleate; Lu 25-109-M
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (Z)-but-2-enedioic acid;5-(2-ethyltetrazol-5-yl)-1-methyl-3,6-dihydro-2H-pyridine
• InChI: InChI=1S/C9H15N5.C4H4O4/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8;5-3(6)1-2-4(7)8/h5H,3-4,6-7H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: YKFYFAAWVQGVTP-BTJKTKAUSA-N
• SMILES: CCN1N=C(N=N1)C2=CCCN(C2)C.C(=C\C(=O)O)\C(=O)O

Alvameline maleate(CAT: I021867) is a muscarinic receptor modulator with dual activity: it acts as a partial agonist at M1 muscarinic receptors and an antagonist at M2 and M3 muscarinic receptors. This selective modulation enhances cholinergic neurotransmission, which is critical for cognitive function, while minimizing peripheral side effects typically associated with non-selective muscarinic activation. Alvameline maleate has been investigated for its potential in treating Alzheimer’s disease and other cognitive disorders, aiming to improve memory and learning by stimulating central cholinergic pathways. Its balanced activity makes it valuable in neurological research focused on cognitive enhancement and neurodegenerative disease management.