Alvelestat

• CAT Number: I005079
• CAS Number: 848141-11-7
• Molecular Formula: C25H22F3N5O4S
• Molecular Weight: 545.53
• Purity: ≥95%
• Synonyms: 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide
• Target: Elastase
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: Store at -20°C
• IC50: 7.9 ± 0.12 (pIC50, Human NE); 4.9 nM (Ki value, Human NE) [1]
• IUPAC Name: 6-methyl-5-(2-methylpyrazol-3-yl)-N-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
• InChI: InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34)
• InChIKey: QNQZWEGMKJBHEM-UHFFFAOYSA-N
• SMILES: O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4

Alvelestat(CAT: I005079) is a potent and selective inhibitor of neutrophil elastase, an enzyme implicated in the degradation of elastin and other extracellular matrix components. It is widely studied for its therapeutic potential in inflammatory and respiratory diseases, including chronic obstructive pulmonary disease (COPD), alpha-1 antitrypsin deficiency-related emphysema, and other conditions characterized by excessive neutrophilic inflammation. By inhibiting neutrophil elastase, Alvelestat reduces tissue damage and inflammation, helping to preserve lung function. Its high specificity and favorable pharmacokinetic profile make it suitable for both in vitro and in vivo studies, advancing research into targeted treatments for neutrophil-driven pathologies.