For research use only. Not for therapeutic Use.
Alvocidib hydrochloride (Cat No.:I001813) is a synthetic small molecule and a potent inhibitor of cyclin-dependent kinases (CDKs). It specifically targets CDK9, a kinase involved in transcriptional regulation, and inhibits its activity. By blocking CDK9, alvocidib disrupts the cell cycle progression and leads to cell cycle arrest and apoptosis in cancer cells. It has shown promise as an anticancer agent in preclinical and clinical studies, particularly in hematological malignancies and solid tumors. Additionally, alvocidib has been investigated for its potential to enhance the efficacy of other anticancer drugs when used in combination therapies.
CAS Number | 131740-09-5 |
Synonyms | Alvocidib; Alvocidib hydrochloride; Flavopiridol; HL 275; HL-275; HMR 1275; HMR-1275; L 86 8275; L86-8275; MDL 107,826A; MDL 107826A; MDL-107826A; NSC 649890.;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one |
Molecular Formula | C21H21Cl2NO5 |
Purity | ≥95% |
Target | Autophagy |
Solubility | Soluble in DMSO, not in water |
Storage | 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months). |
Related CAS | 146426-40-6(free base) |
IUPAC Name | 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride |
InChI | InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1 |
InChIKey | LGMSNQNWOCSPIK-LWHGMNCYSA-N |
SMILES | CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl |
Reference | 1. Semin Oncol. 2002 Jun;29(3 Suppl 11):77-85. <br /> |
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