ALX-5407 hydrochloride

• CAT Number: R013115
• CAS Number: 200006-08-2
• Molecular Formula: C24H25ClFNO3
• Molecular Weight: 429.91
• Purity: ≥95%
• Synonyms: 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid;hydrochloride
• InChI: InChI=1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1
• InChIKey: RPDGSZCYSJWQEE-GNAFDRTKSA-N
• SMILES: CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl

ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].
ALX-5407 hydrochloride (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [3H]glycine uptake in rat brain and QT6-1C cells with an IC50 value of 3 nM[1].
ALX-5407 hydrochloride (50 nM) shows slow dissociation kinetics in QT6-1C cells[1].
ALX-5407 hydrochloride (1 and 10 mg/kg; oral administration, once) increases free glycine levels in rat prefrontal cortex[1].

Reference

[1]. Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.
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