For research use only. Not for therapeutic Use.
AM-0902 (Cat No.:I003544) is a potent and selective transient receptor potential A1 (TRPA1) antagonist with IC50 values of 71 and 131 nM for rTRPA1 and hTRPA1, respectively, and is effective in combination with an important role in pain-related biological pathways.
| Catalog Number | I003544 |
| CAS Number | 1883711-97-4 |
| Synonyms | AM-0902; AM 0902; AM0902.;1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one |
| Molecular Formula | C17H15ClN6O2 |
| Purity | ≥95% |
| Target | TRPA1 Antagonist |
| Solubility | Soluble in DMSO, not in water |
| Storage | 2-8°C |
| IUPAC Name | 1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one |
| InChI | InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 |
| InChIKey | AWJBWNUUODWOKQ-UHFFFAOYSA-N |
| SMILES | CN1C=NC2=C1C(=O)N(C=N2)CC3=NC(=NO3)CCC4=CC=C(C=C4)Cl |
| Reference | </br>Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity</br> Laurie B. Schenkel, Philip R. Olivieri, Alessandro A. Boezio, Holly L. Deak, Renee Emkey, Russell F. Graceffa, Hakan Gunaydin, Angel Guzman-Perez, Josie H. Lee, Yohannes Teffera, Weiya Wang, Beth D. Youngblood, Violeta L. Yu, Maosheng Zhang, Narender R. Gavva, Sonya G. Lehto, and Stephanie Geuns-Meye. Publication Date (Web): March 4, 2016 (Article); DOI: 10.1021/acs.jmedchem.6b00039</br> |
