AM 281

• CAT Number: R016034
• CAS Number: 202463-68-1
• Molecular Formula: C21H19Cl2IN4O2
• Molecular Weight: 557.21
• Purity: ≥95%
• Synonyms: 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: Desiccate at +4C
• IUPAC Name: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide
• InChI: InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
• InChIKey: AJFFBPZYXRNAIC-UHFFFAOYSA-N
• SMILES: CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I

AM 281(CAT: R016034) is a selective antagonist of the cannabinoid receptor type 1 (CB1), commonly used in research to study the endocannabinoid system. By blocking the activity of CB1 receptors, AM 281 is useful for investigating the physiological and neurological roles of cannabinoids, including their involvement in pain modulation, appetite regulation, and psychoactive effects. This compound has been employed in preclinical studies to explore potential therapeutic strategies for conditions such as obesity, addiction, and mood disorders. AM 281’s selectivity for CB1 makes it a valuable tool for dissecting cannabinoid signaling pathways without affecting CB2 receptors.