For research use only. Not for therapeutic Use.
Na+ channel blocker; neuroprotective agent.
KEYWORDS: AM 36 dihydrochloride | supplier | Na+ channel Blocker | CNSB002 | AM36 |CAS[199467-52-2] | Sodium | Blocker | Ion Channels | Nav1.3 | Nav1.7 | Nav1.8 | neuropathic pain | analgesic | neuroprotective |ROS
| Catalog Number | I047494 |
| CAS Number | 1246094-77-8 |
| Molecular Formula | C27H39ClN2O2.2HCl |
| Purity | ≥95% |
| IUPAC Name | 2,6-ditert-butyl-4-[[4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazin-1-yl]methyl]phenol;dihydrochloride |
| InChI | InChI=1S/C27H39ClN2O2.2ClH/c1-26(2,3)22-15-19(16-23(25(22)32)27(4,5)6)17-29-11-13-30(14-12-29)18-24(31)20-7-9-21(28)10-8-20;;/h7-10,15-16,24,31-32H,11-14,17-18H2,1-6H3;2*1H |
| SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CN2CCN(CC2)CC(C3=CC=C(C=C3)Cl)O.Cl.Cl |
| Reference | J. K. Callaway et al. Delayed Treatment With AM-36, a Novel Neuroprotective Agent, Reduces Neuronal Damage After Endothelin-1–Induced Middle Cerebral Artery Occlusion in Conscious Rats. Stroke. 1999, 30, 2704-2712.
J. K Callaway et al. Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis. Br. J. Pharmacol. 2001, 132, 1691–1698.
A. Kolosov et al. Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. Pain Med. 2010 Jan;11(1):106-18. |
